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This part of the problem regulates reward responses in acquiring food and sex, plus nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you need to err along the side of caution and allow FDA do its job and demand some research be done in order that the public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to earn money and that they would say almost anything to keep people on their own medications. Researchers found that participants investing in this drug for any year, lost excess weight within 4 weeks and have kept the weight off through the entire 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them more potent and safer. Combo-pilling will be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that as of right now there are not any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug can also raise blood pressure level and heart rate, and mustn't be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must not used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. BioCorRx, Inc.'s naltrexone implant isn't bigger than a thumb and is inserted beneath the patient's skin via a 30-minute, minimally invasive outpatient procedure created by a healthcare professional. The implant is administered in BioCorRx, Inc.'s Start Fresh Program which can be distributed in numerous states by independent rehabilitation facilities.

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