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Researchers found that participants investing in this drug for a year, dropped a few pounds within a month and have kept the extra weight off through the entire 56 weeks of the study. Contrave is often a combination with the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, which may make them far better and safer. Combo-pilling could be the newest fad or in addition to this the newest into the future under scrutiny and so it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular is the fact that since right now there are not any long term prescription weightloss pills that have been licensed by the FDA besides orlistat. 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