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This the main problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both once they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err on the side of caution and allow the FDA do its job and demand some investigation be done in order that the public understands the side effects and risks of the medications before we drive them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on their own medications. Researchers found out that participants using this drug for the year, lost weight within a month and have kept the extra weight off throughout the 56 weeks of the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs that are made up of several active ingredient, which may make them more efficient and safer. Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is now popular is the fact that as of right now there aren't long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug may also raise blood pressure levels and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high hypertension, as well as by you aren't heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients for the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. Other people who should not use Contrave are patients being affected by bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave should not be prescribed for females who are pregnant or wanting to become pregnant.

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