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This the main problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both once they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err on the side of caution and allow the FDA do its job and demand some investigation be done in order that the public understands the side effects and risks of the medications before we drive them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on their own medications. 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The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug may also raise blood pressure levels and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high hypertension, as well as by you aren't heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. 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